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Conserved immuno‐collagenic subtypes predict response to immune checkpoint blockade

20 Mar 2024

Abstract excerpt

BACKGROUND: Immune checkpoint blockade (ICB) has revolutionized the treatment of various cancer types. Despite significant preclinical advancements in understanding mechanisms, identifying the molecular basis and predictive biomarkers for clinical ICB responses remains challenging. Recent evidence, both preclinical and clinical, underscores the pivotal role of the extracellular matrix (ECM) in modulating immune...

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PMID: 38507505
DOI: 10.1002/cac2.12538

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