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Distinct evolutionary patterns of tumour-immune escape and elimination determined by extracellular matrix architectures

1 Jul 2025

Abstract excerpt

Cancer progression remains a significant clinical challenge. Phenotypic adaptation by tumour cells results in disease heterogeneity, which drives treatment resistance and immune escape. T-cell immunotherapy, while effective at treating some cancer subtypes, can also fail due to limits on tumour immunogenicity or T-cell recognition. For example, one potential contributor to immune escape involves the density and...

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PMID: 40631902
DOI: 10.1098/rsif.2025.0116

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