Article

Collagen density regulates the activity of tumor-infiltrating T cells

2018-12-12

Abstract excerpt

<h4>Background</h4> Tumor progression is accompanied by dramatic remodeling of the surrounding extracellular matrix leading to the formation of a tumor-specific ECM, which is often more collagen-rich and of increased stiffness. The altered ECM of the tumor supports cancer growth and metastasis, but it is unknown if this effect involves modulation of T cell activity. To investigate if a high-density tumor-specific...

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Literature Corpus work: 1cd2ef70-5d6b-5456-92fa-2c514e65e23d
DOI: 10.1101/493437

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