Article

Axon guidance genes are regulated by TDP-43 and RGNEF through the rate of long-intron processing

2023-12-07

Abstract excerpt

Rho guanine nucleotide exchange factor (RGNEF) is a guanine nucleotide exchange factor (GEF) mainly involved in regulating the activity of Rho-family GTPases. Previous work has shown that RGNEF inclusions in the spinal motor neurons of ALS patients co-localise with TDP-43, the major RNA binding protein aggregating in the brain and spinal cord of ALS patients. To further characterise their relationship, we have com...

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Literature Corpus work: 2d9e3d49-9fe0-59de-bfea-7c91e22356ba
DOI: 10.1101/2023.12.05.570131

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