Article
Dynamic m6A modification regulates local translation of mRNA in axons.
Nucleic acids research - 16 Feb 2018
Yu Jun, Chen Mengxian, Huang Haijiao, Zhu Junda, Song Huixue, Zhu Jian, Park Jaewon, Ji Sheng-Jian
Abstract excerpt
N6-methyladenosine (m6A) is a reversible modification in mRNA and has been shown to regulate processing, translation and decay of mRNA. However, the roles of m6A modification in neuronal development are still not known. Here, we found that the m6A eraser FTO is enriched in axons and can be locally translated. Axon-specific inhibition of FTO by rhein, or compartmentalized siRNA knockdown of Fto in axons led to...
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