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Article

Inclusion Formation and Toxicity of the ALS Protein RGNEF and Its Association with the Microtubule Network.

International journal of molecular sciences - 5 Aug 2020

Di Gregorio Sonja E, Volkening Kathryn, Strong Michael J, Duennwald Martin L

Abstract excerpt

The Rho guanine nucleotide exchange factor (RGNEF) protein encoded by the ARHGEF28 gene has been implicated in the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Biochemical and pathological studies have shown that RGNEF is a component of the hallmark neuronal cytoplasmic inclusions in ALS-affected neurons. Additionally, a heterozygous mutation in ARHGEF28 has been identified in a number of...

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PMID: 32764283
DOI: 10.3390/ijms21165597
PMCID: PMC7460592

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