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Crosstalk between the Rho and Rab family of small GTPases in neurodegenerative disorders

27 Jan 2023

Abstract excerpt

Neurodegeneration is associated with defects in cytoskeletal dynamics and dysfunctions of the vesicular trafficking and sorting systems. In the last few decades, studies have demonstrated that the key regulators of cytoskeletal dynamics are proteins from the Rho family GTPases, meanwhile, the central hub for vesicle sorting and transport between target membranes is the Rab family of GTPases. In this regard, the...

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PMID: 36779014
DOI: 10.3389/fncel.2023.1084769

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