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Article

Mitigation of TDP-43 toxic phenotype by an RGNEF fragment in amyotrophic lateral sclerosis models.

Brain : a journal of neurology - 3 Jun 2024

Droppelmann Cristian A, Campos-Melo Danae, Noches Veronica, McLellan Crystal, Szabla Robert, Lyons Taylor A, Amzil Hind, Withers Benjamin, Kaplanis Brianna, Sonkar Kirti S, Simon Anne, Buratti Emanuele, Junop Murray, Kramer Jamie M, Strong Michael J

Abstract excerpt

Aggregation of the RNA-binding protein TAR DNA binding protein (TDP-43) is a hallmark of TDP-proteinopathies including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). As TDP-43 aggregation and dysregulation are causative of neuronal death, there is a special interest in targeting this protein as a therapeutic approach. Previously, we found that TDP-43 extensively co-aggregated with the dual...

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PMID: 38739752
DOI: 10.1093/brain/awae078
PMCID: PMC11146434

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