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Article

TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR

25 Nov 2011

Abstract excerpt

TDP-43 is linked to neurodegenerative diseases including frontotemporal dementia and amyotrophic lateral sclerosis. Mostly localized in the nucleus, TDP-43 acts in conjunction with other ribonucleoproteins as a splicing co-factor. Several RNA targets of TDP-43 have been identified so far, but its role(s) in pathogenesis remains unclear. Using Affymetrix exon arrays, we have screened for the first time for...

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PMID: 22121224
DOI: 10.1093/nar/gkr1082

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