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Article

TDP‐43, the signature protein of FTLD‐U, is a neuronal activity‐responsive factor

14 Dec 2007

Abstract excerpt

TDP-43, recently identified as a signature protein of the pathogenic inclusions in the brains cells of frontotemporal lobar degeneration patients, is a 43 kDa RNA-binding protein. It has been known mainly as a nuclear factor capable of repressing transcription and promoting exon exclusion. TDP-43 also forms distinct nuclear substructures linking different types of nuclear bodies. In this study, we provide the...

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PMID: 18088371
DOI: 10.1111/j.1471-4159.2007.05190.x

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