Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Computational insights and impact of combinatorial peptidomimetics on immune escape SARS-CoV-2 variants.

Expert opinion on drug discovery - 1 Mar 2026

Losery Stanly Paul Matam, Laddha Kapil, Martinek Tamás A, Sobhia M Elizabeth

Abstract excerpt

BACKGROUND: The SARS-CoV-2 receptor-binding domain (RBD) undergoes frequent mutations, weakening current therapeutics. Despite its importance in viral entry, most inhibitors lack resilience to antigenic drift, emphasizing the need for broad-spectrum agents that maintain binding across variants while preserving host specificity. RESEARCH DESIGN AND METHODS: The authors employed computational mutagenesis to design...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to COVID-19 Drug Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Design

Share to Immune Evasion

Share to Molecular Dynamics Simulation

Share to Mutation

Share to SARS-CoV-2

Share to Spike Glycoprotein, Coronavirus

Source

Identifiers

PMID: 41731696
DOI: 10.1080/17460441.2026.2625825

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Computational insights and impact of combinatorial peptidomimetics on immune escape SARS-CoV-2 variants.PMID 41731696Read ↗

Preemptive optimization of a clinical antibody for broad neutralization of SARS-CoV-2 variants and robustness against viral escapeSemantic proximity Read ↗

In silico study identifies peptide inhibitors that negate the effect of non-synonymous mutations in major drug targets of SARS-CoV-2 variants.Semantic proximity Read ↗

Application of an integrated computational antibody engineering platform to design SARS-CoV-2 neutralizersSemantic proximity Read ↗

Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in miceSemantic proximity Read ↗

Peptide Antidotes to SARS-CoV-2 (COVID-19)Semantic proximity Read ↗

From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 VariantsSemantic proximity Read ↗

Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variantSemantic proximity Read ↗

Ensovibep, a novel trispecific DARPin candidate that protects against SARS-CoV-2 variantsSemantic proximity Read ↗

Peptide-antibody Fusions Engineered by Phage Display Exhibit Ultrapotent and Broad Neutralization of SARS-CoV-2 VariantsSemantic proximity Read ↗

Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations.Semantic proximity Read ↗

Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccinesSemantic proximity Read ↗

High Throughput Virtual Screening and Validation of a SARS-CoV-2 Main Protease Non-Covalent InhibitorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.