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Article

Molecular characteristics of breast tumors in patients screened for germline predisposition from a population-based observational study.

Genome medicine - 14 Apr 2023

Nacer Deborah F, Vallon-Christersson Johan, Nordborg Nicklas, Ehrencrona Hans, Kvist Anders, Borg Åke, Staaf Johan

Abstract excerpt

BACKGROUND: Pathogenic germline variants (PGVs) in certain genes are linked to higher lifetime risk of developing breast cancer and can influence preventive surgery decisions and therapy choices. Public health programs offer genetic screening based on criteria designed to assess personal risk and identify individuals more likely to carry PGVs, dividing patients into screened and non-screened groups. How tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37060015
DOI: 10.1186/s13073-023-01177-4
PMCID: PMC10103478

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