Article
Concordance of genomic alterations between primary and recurrent breast cancer.
Molecular cancer therapeutics - 1 May 2014
Meric-Bernstam Funda, Frampton Garrett M, Ferrer-Lozano Jaime, Yelensky Roman, Pérez-Fidalgo Jose A, Wang Ying, Palmer Gary A, Ross Jeffrey S, Miller Vincent A, Su Xiaoping, Eroles Pilar, Barrera Juan Antonio, Burgues Octavio, Lluch Ana M, Zheng Xiaofeng, Sahin Aysegul, Stephens Philip J, Mills Gordon B, Cronin Maureen T, Gonzalez-Angulo Ana M
Abstract excerpt
There is growing interest in delivering genomically informed cancer therapy. Our aim was to determine the concordance of genomic alterations between primary and recurrent breast cancer. Targeted next-generation sequencing was performed on formalin-fixed paraffin-embedded (FFPE) samples, profiling 3,320 exons of 182 cancer-related genes plus 37 introns from 14 genes often rearranged in cancer. Point mutations,...
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