Article

Pseudouridines in the U2 Branch Site Recognition Region Differentially Contribute to Branch Site Recognition during Pre-mRNA Splicing

2026-08-10

Abstract excerpt

Pseudouridines (Ψs) are highly enriched in conserved, functionally critical regions of spliceosomal snRNAs, particularly within the U2 branch site recognition region (BSRR), which contains six Ψs in humans and three in S. cerevisiae . To investigate how U2 BSRR pseudouridylation influences branch site sequence (BSS) recognition, we developed a large-scale, high-throughput screening system in S. cerevisiae that a...

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Literature Corpus work: 2d775ba8-012a-5b66-9ca8-7e8db392a192
DOI: 10.64898/2026.08.09.743773

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