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Article

Elements essential for accumulation and function of small nucleolar RNAs directing site-specific pseudouridylation of ribosomal RNAs.

The EMBO journal - 15 Jan 1999

Bortolin M L, Ganot P, Kiss T

Abstract excerpt

During site-specific pseudouridylation of eukaryotic rRNAs, selection of correct substrate uridines for isomerization into pseudouridine is directed by small nucleolar RNAs (snoRNAs). The pseudouridylation guide snoRNAs share a common 'hairpin-hinge- hairpin-tail' secondary structure and two conserved sequence motifs, the H and ACA boxes, located in the single-stranded hinge and tail regions, respectively. In the...

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Identifiers

PMID: 9889201
DOI: 10.1093/emboj/18.2.457
PMCID: PMC1171139

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