Article
Elements essential for accumulation and function of small nucleolar RNAs directing site-specific pseudouridylation of ribosomal RNAs.
The EMBO journal - 15 Jan 1999
Bortolin M L, Ganot P, Kiss T
Abstract excerpt
During site-specific pseudouridylation of eukaryotic rRNAs, selection of correct substrate uridines for isomerization into pseudouridine is directed by small nucleolar RNAs (snoRNAs). The pseudouridylation guide snoRNAs share a common 'hairpin-hinge- hairpin-tail' secondary structure and two cons...
Topics
- Base Sequence
- Binding Sites
- Gene Expression
- Humans
- In Vitro Techniques
- Introns
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Plasmids
- Pseudouridine
- RNA