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Article

Deep mutational scanning of influenza A virus neuraminidase facilitates the identification of drug resistance mutations in vivo.

mSystems - 26 Oct 2023

Wang Sihan, Zhang Tian-Hao, Hu Menglong, Tang Kejun, Sheng Li, Hong Mengying, Chen Dongdong, Chen Liubo, Shi Yuan, Feng Jun, Qian Jing, Sun Lifeng, Ding Kefeng, Sun Ren, Du Yushen

Abstract excerpt

IMPORTANCE: NA is a crucial surface antigen and drug target of influenza A virus. A comprehensive understanding of NA's mutational effect and drug resistance profiles in vivo is essential for comprehending the evolutionary constraints and making informed choices regarding drug selection to combat resistance in clinical settings. In the current study, we established an efficient deep mutational screening system in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37772870
DOI: 10.1128/msystems.00670-23
PMCID: PMC10654105

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