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Article

The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation.

The Journal of experimental medicine - 1 Feb 2021

Mori Daiki, Grégoire Claude, Voisinne Guillaume, Celis-Gutierrez Javier, Aussel Rudy, Girard Laura, Camus Mylène, Marcellin Marlène, Argenty Jérémy, Burlet-Schiltz Odile, Fiore Frédéric, Gonzalez de Peredo Anne, Malissen Marie, Roncagalli Romain, Malissen Bernard

Abstract excerpt

To determine the respective contribution of the LAT transmembrane adaptor and CD5 and CD6 transmembrane receptors to early TCR signal propagation, diversification, and termination, we describe a CRISPR/Cas9-based platform that uses primary mouse T cells and permits establishment of the composition of their LAT, CD5, and CD6 signalosomes in only 4 mo using quantitative mass spectrometry. We confirmed that positive...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Differentiation, T-Lymphocyte

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Source

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Identifiers

PMID: 33125054
DOI: 10.1084/jem.20201011
PMCID: PMC7608068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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