Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice.

doi:10.7554/eLife.74419

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Article

Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice.

eLife - 3 Feb 2022

Smith Clare M, Baker Richard E, Proulx Megan K, Mishra Bibhuti B, Long Jarukit E, Park Sae Woong, Lee Ha-Na, Kiritsy Michael C, Bellerose Michelle M, Olive Andrew J, Murphy Kenan C, Papavinasasundaram Kadamba, Boehm Frederick J, Reames Charlotte J, Meade Rachel K, Hampton Brea K, Linnertz Colton L, Shaw Ginger D, Hock Pablo, Bell Timothy A, Ehrt Sabine, Schnappinger Dirk, Pardo-Manuel de Villena Fernando, Ferris Martin T, Ioerger Thomas R, Sassetti Christopher M

Abstract excerpt

The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the pathogen's ability to adapt to the variable immune pressures exerted by the host. Understanding this interplay has proven difficult, largely because experimentally tractable animal models do not recapitulate the heterogeneity of tuberculosis disease. We leveraged the genetically diverse Collaborative Cross (CC) mouse panel in...

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Identifiers

PMID: 35112666
DOI: 10.7554/eLife.74419
PMCID: PMC8846590

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