Article

The Mediator CDK8-Cyclin C complex modulates vein patterning in <i>Drosophila</i> by stimulating Mad-dependent transcription

2018-07-03

Abstract excerpt

Dysregulations of CDK8 and its regulatory partner CycC, two subunits of the conserved Mediator complex, have been linked to diverse human diseases such as cancer, thus it is essential to understand the regulatory network mobilizing the CDK8-CycC complex in both normal development and tumorigenesis. To identify upstream regulators or downstream effectors of CDK8, we performed a dominant modifier genetic screen in...

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Literature Corpus work: 2d39465f-c2a0-52ba-b19a-459267a2025e
DOI: 10.1101/360628

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