Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cdk8 is essential for preimplantation mouse development.

Molecular and cellular biology - 1 Sept 2007

Westerling Thomas, Kuuluvainen Emilia, Mäkelä Tomi P

Abstract excerpt

The Cdk8 kinase and associated proteins form a nonessential transcriptional repressor module of the Mediator in the budding yeast Saccharomyces cerevisiae. Genetic analyses of this module have demonstrated functions ranging from environmental responses in budding yeast to organogenesis and development in worms, flies, and zebrafish. Here we have investigated the function of mammalian Cdk8 using mice harboring a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blastocyst
Share to Cell Line
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinases

Share to Genotype

Share to Mice, Knockout

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 17620419
DOI: 10.1128/MCB.01302-06
PMCID: PMC1952144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cdk8 is essential for preimplantation mouse development.PMID 17620419Read ↗

The two faces of Cdk8, a positive/negative regulator of transcription.Semantic proximity Read ↗

Conditional deletions refine the embryonic requirement for Dlk1Semantic proximity Read ↗

CHK1-CDC25A-CDK1 regulate cell cycle progression in early mouse embryos to protect genome integritySemantic proximity Read ↗

Targeted inactivation of p12, CDK2 associating protein 1, leads to early embryonic lethality.Semantic proximity Read ↗

Molecular and in vivo Functions of the CDK8 and CDK19 Kinase ModulesSemantic proximity Read ↗

Pathogenesis of CDK8-associated disorder: two patients with novel CDK8 variants and in vitro and in vivo functional analyses of the variantsSemantic proximity Read ↗

Cdk2 and Cdk4 cooperatively control the expression of Cdc2.Semantic proximity Read ↗

Distinct effects of CDK8 module subunits on cellular growth and proliferation in <i>Drosophila</i>Semantic proximity Read ↗

Role of <i>Filia</i> , a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesisSemantic proximity Read ↗

Cyclin-dependent kinases and rare developmental disordersSemantic proximity Read ↗

Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination.Semantic proximity Read ↗

A subcortical maternal complex essential for preimplantation mouse embryogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.