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A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition

20 Oct 2022

Abstract excerpt

Menin interacts with oncogenic MLL1-fusion proteins, and small molecules that disrupt these associations are in clinical trials for leukemia treatment. By integrating chromatin-focused and genome-wide CRISPR screens with genetic, pharmacologic, and biochemical approaches, we discovered a conserved molecular switch between the MLL1-Menin and MLL3/4-UTX chromatin-modifying complexes that dictates response to...

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PMID: 36264143
DOI: 10.1158/2159-8290.cd-22-0416

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