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Article

Menin critically links MLL proteins with LEDGF on cancer-associated target genes.

Cancer cell - 8 Jul 2008

Yokoyama Akihiko, Cleary Michael L

Abstract excerpt

Menin displays the unique ability to either promote oncogenic function in the hematopoietic lineage or suppress tumorigenesis in the endocrine lineage; however, its molecular mechanism of action has not been defined. We demonstrate here that these discordant functions are unified by menin's ability to serve as a molecular adaptor that physically links the MLL (mixed-lineage leukemia) histone methyltransferase...

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Share to Chromatin Assembly and Disassembly
Share to Gene Expression Regulation, Leukemic
Share to Histone Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiple Endocrine Neoplasia Type 1

Share to Myeloid-Lymphoid Leukemia Protein

Share to Myeloid Progenitor Cells

Share to Protein Methyltransferases

Share to U937 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 18598942
DOI: 10.1016/j.ccr.2008.05.003
PMCID: PMC2692591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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