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Molecular Basis of the Mixed Lineage Leukemia-Menin Interaction

20 Oct 2010

Abstract excerpt

Chromosomal translocations targeting the mixed lineage leukemia (MLL) gene result in MLL fusion proteins that are found in aggressive human acute leukemias. Disruption of MLL by such translocations leads to overexpression of Hox genes, resulting in a blockage of hematopoietic differentiation that ultimately leads to leukemia. Menin, which directly binds MLL, has been identified as an essential oncogenic co-factor...

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PMID: 20961854
DOI: 10.1074/jbc.m110.172783

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