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Menin is necessary for long term maintenance of meningioma-1 driven leukemia

4 Feb 2021

Abstract excerpt

Translocations of Meningioma-1 (MN1) occur in a subset of acute myeloid leukemias (AML) and result in high expression of MN1, either as a full-length protein, or as a fusion protein that includes most of the N-terminus of MN1. High levels of MN1 correlate with poor prognosis. When overexpressed in murine hematopoietic progenitors, MN1 causes an aggressive AML characterized by an aberrant myeloid precursor-like...

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PMID: 33542482
DOI: 10.1038/s41375-021-01146-z

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