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Article

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jan 2006

Chen Ya-Xiong, Yan Jizhou, Keeshan Karen, Tubbs Anthony T, Wang Haoren, Silva Albert, Brown Eric J, Hess Jay L, Pear Warren S, Hua Xianxin

Abstract excerpt

Menin is the product of the tumor suppressor gene Men1 that is mutated in the inherited tumor syndrome multiple endocrine neoplasia type 1 (MEN1). Menin has been shown to interact with SET-1 domain-containing histone 3 lysine 4 (H3K4) methyltransferases including mixed lineage leukemia proteins to regulate homeobox (Hox) gene expression in vitro. Using conditional Men1 knockout mice, we have investigated the...

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Source

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Identifiers

PMID: 16415155
DOI: 10.1073/pnas.0510347103
PMCID: PMC1326489

Genes

MEN1
SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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