Article
Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer's Disease.
Current protein & peptide science - 1 Jan 2020
Narayanan Siju Ellickal, Sekhar Nikhila, Rajamma Rajalakshmi Ganesan, Marathakam Akash, Al Mamun Abdullah, Uddin Md Sahab, Mathew Bijo
Abstract excerpt
Alzheimer's disease (AD) is a progressive brain disorder and one of the most common causes of dementia and death. AD can be of two types; early-onset and late-onset, where late-onset AD occurs sporadically while early-onset AD results from a mutation in any of the three genes that include amyloid precursor protein (APP), presenilin 1 (PSEN 1) and presenilin 2 (PSEN 2). Biologically, AD is defined by the presence...
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