Article

A pre-rRNA positive feedback loop drives malignant ribosome biogenesis

2026-07-03

Abstract excerpt

Altered nucleoli are a well-established hallmark of cancer 1 , but how oncogenic signalling remodels the nucleolus remains poorly understood. Here we used an inducible mouse model of pancreatic ductal adenocarcinoma (PDAC) 2 to generate spatially resolved proteomic and phosphoproteomic maps of the nucleolus upon RAS oncogene activation. We identify a phosphorylation programme initiated by translocation of the Ca...

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Literature Corpus work: 2ccc7add-a498-573e-b0a7-c5c2d67b7dbe
DOI: 10.64898/2026.07.03.736202

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