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Article

Ribosome biogenesis: Achilles heel of cancer?

22 Jun 2014

Abstract excerpt

It is long been known that cancer and non-cancer cells can be distinguished on the basis of their nucleolar morphologies. As early as the 19th century, it was reported that cancer cells have larger and more irregularly shaped nucleoli. Since then, pathologists have used nucleolar morphology to predict the clinical outcome [1]. Nucleolar morphology is altered due to the up-regulation of ribosomal gene...

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PMID: 25061498
DOI: 10.18632/genesandcancer.14

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