Article
BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction.
Journal of molecular cell biology - 1 Jun 2017
Ba Qian, Li Xiaoguang, Huang Chao, Li Junyang, Fu Yijing, Chen Peizhan, Duan Juan, Hao Miao, Zhang Yinghua, Li Jingquan, Sun Chuanqi, Ying Hao, Song Haiyun, Zhang Ruiwen, Shen Zhiyuan, Wang Hui
Abstract excerpt
Extraribosomal functions of ribosomal proteins (RPs) have gained much attention for their implications in tumorigenesis and progression. However, the regulations for transition between the ribosomal and extraribosomal functions of RPs are rarely reported. Herein, we identified a ribosomal protein S7-interacting partner, BCCIPβ, which modulates the functional conversion of S7. Through the N-terminal acidic domain,...
Topics
- Binding Sites
- Calcium-Binding Proteins
- Cell Cycle Proteins
- HEK293 Cells
- Humans
- Immunoprecipitation
- Mutation
- Neoplasms
- Nuclear Proteins
- Protein Interaction Mapping