Article
Multi-omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer.
EMBO molecular medicine - 7 Jun 2023
Stentenbach Maike, Ermer Judith A, Rudler Danielle L, Perks Kara L, Raven Samuel A, Lee Richard G, McCubbin Tim, Marcellin Esteban, Siira Stefan J, Rackham Oliver, Filipovska Aleksandra
Abstract excerpt
Prostate cancer is the most commonly diagnosed malignancy and the third leading cause of cancer deaths. GWAS have identified variants associated with prostate cancer susceptibility; however, mechanistic and functional validation of these mutations is lacking. We used CRISPR-Cas9 genome editing to introduce a missense variant identified in the ELAC2 gene, which encodes a dually localised nuclear and mitochondrial...
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