Article

Role of MNX1-mediated Histone Modifications and PBX Gene Family in MNX1-induced Leukemogenesis

2025-09-25

Abstract excerpt

<title>Abstract</title> <p> The t(7;12)(q36;p13) AML subtype in pediatric patients is associated with the upregulation of homeodomain protein MNX1 as the initiating event for leukemogenesis. In this study, we investigated the downstream targets of MNX1 and their relationship to MNX1-induced histone modifications. Using a comprehensive approach combining TMT mass spectrometry, RNA-sequencing, qPCR, antibody-guide...

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Literature Corpus work: 2cbef429-3616-5e0e-b323-a2b978be6cd4
DOI: 10.21203/rs.3.rs-6480114/v1

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