Article

Aberrant MNX1 Expression Associated with t(7;12)(q36;p13) Pediatric Acute Myeloid Leukemia Induces the Disease Through Altering Histone Methylation

2022-06-12

Abstract excerpt

<h4>ABSTRACT</h4> Certain subtypes of acute myeloid leukemia (AML) in children have inferior outcome. One of these has a translocation t(7;12)(q36;p13) leading to a MNX1 :: ETV6 fusion along with high expression of MNX1. Here we identified the transforming event in this AML and possible ways of treatment. Only MNX1 was able to induce AML in mice, with similar gene expression and pathway enrichment to t(7;12) AM...

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Literature Corpus work: afb3663e-eca5-5719-95f7-655020754374
DOI: 10.1101/2022.06.10.495634

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