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Altered enhancer-promoter interaction leads to <i>MNX1</i> expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)

2023-09-17

Abstract excerpt

Acute myeloid leukemia (AML) with the t(7;12)(q36;p13) translocation occurs only in very young children and has a poor clinical outcome. The expected oncofusion between breakpoint partners ( MNX1 and ETV6 ) has only been reported in a subset of cases. However, a universal feature is the strong transcript and protein expression of MNX1, a homeobox transcription factor that is normally not expressed in hematopoiet...

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Literature Corpus work
b9fd2a94-8d04-5a1a-844e-ed6326835b87
DOI
10.1101/2023.09.13.557546
Open publication

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Altered enhancer-promoter interaction leads to <i>MNX1</i> expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)DOI 10.1101/2023.09.13.557546
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