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Article

Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking

22 Mar 2023

Abstract excerpt

Recurrent translocations are common in acute myeloid leukemia (AML) and important for cytogenetic classification and prognosis [ 1 ]. AML-derived leukemic cell lines have been essential to study molecular defects and to develop novel therapeutic approaches [ 2 , 3 ]. The leukemic cell line GDM-1 was established from a patient with acute myelomonoblastic leukemia [ 4 ]. GDM-1 cells carry a reciprocal translocation...

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PMID: 36949154
DOI: 10.1038/s41375-023-01865-5

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