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Mechanisms associated with t(7;12) acute myeloid leukaemia: from genetics to potential treatment targets

1 Jan 2023

Abstract excerpt

Acute myeloid leukaemia (AML), typically a disease of elderly adults, affects 8 children per million each year, with the highest paediatric incidence in infants aged 0-2 of 18 per million. Recurrent cytogenetic abnormalities contribute to leukaemia pathogenesis and are an important determinant of leukaemia classification. The t(7;12)(q36;p13) translocation is a high-risk AML subtype exclusively associated with...

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PMID: 36622782
DOI: 10.1042/bsr20220489

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