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Elevated HOX gene expression in acute myeloid leukemia is associated with NPM1 mutations and poor survival

10 Jun 2019

Abstract excerpt

Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic progenitor cells and the most common malignant myeloid disorder in adults. Several gene mutations such as in NPM1 (nucleophosmin 1) are involved in the pathogenesis and progression of AML. The aim of this study was to identify genes whose expression is associated with driver mutations and survival outcome. Genotype data (somatic mutations) and...

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PMID: 31333881
DOI: 10.1016/j.jare.2019.05.006

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