Article
Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging.
Aging cell - 1 May 2020
Novais Emanuel J, Tran Victoria A, Miao Jingya, Slaver Katie, Sinensky Andrew, Dyment Nathaniel A, Addya Sankar, Szeri Flora, van de Wetering Koen, Shapiro Irving M, Risbud Makarand V
Abstract excerpt
Intervertebral disc degeneration presents a wide spectrum of clinically degenerative disc phenotypes; however, the contribution of genetic background to the degenerative outcomes has not been established. We characterized the spinal phenotype of 3 mouse strains with varying cartilage-regenerative potential at 6 and 23 months: C57BL/6, LG/J and SM/J. All strains showed different aging phenotypes. Importantly, LG/J...
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