Article

LASSO: versatile and selective biomolecule pulldown with combinatorial DNA-crosslinked polymers

2025-07-26

Abstract excerpt

Current methods for sequence-selective biomolecule isolation suffer from high cost, off-target effects, and limited flexibility. Here, we introduce LASSO (cross L ink- A ssisted S equence- S elective is O lation), a versatile platform using programmable polymer phase separation to capture biomolecules under native conditions. LASSO relies on combinatorial crosslinker libraries —diverse mixtures of DNA stran...

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Identifiers and source

Literature Corpus work: 2cb7453a-96be-5a52-85bc-2ca6c2464c14
DOI: 10.1101/2025.07.24.666000

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