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NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing

9 Nov 2023

Abstract excerpt

The blood proteome holds great promise for precision medicine but poses substantial challenges due to the low abundance of most plasma proteins and the vast dynamic range of the plasma proteome. Here we address these challenges with NUcleic acid Linked Immuno-Sandwich Assay (NULISA™), which improves the sensitivity of traditional proximity ligation assays by ~10,000-fold to attomolar level, by suppressing assay...

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PMID: 37945559
DOI: 10.1038/s41467-023-42834-x

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