Article

Mitigating Cellular Dysfunction by Addressing Contaminants in Synthetic circRNA

2024-09-21

Abstract excerpt

Synthetic circular RNA (circRNA) shows great potential in biomedical research and therapies, but impurities introduced during its synthesis can undermine circRNA efficacy. This study investigated the immunogenic potential of byproducts generated during its production. We found that trace amounts of double-stranded RNA in high molecular weight impurities, 5’ triphosphates of uncircularized RNA or small intron fragm...

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Literature Corpus work: 64c1a24a-316f-50a5-903b-0f50be6d7f2f
DOI: 10.1101/2024.09.17.613157

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