Article

A smart polymer for sequence-selective binding, pulldown, and release of DNA targets

2019-03-14

Abstract excerpt

Selective isolation of DNA is crucial for applications in biology, bionanotechnology, clinical diagnostics and forensics. We herein report a smart methanol-responsive polymer (MeRPy) that can be programmed to bind and separate single- as well as double-stranded DNA targets. Captured targets are quickly isolated and released back into solution by denaturation (sequence-agnostic) or toehold-mediated strand displacem...

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Literature Corpus work: b7998ba2-a13f-52f6-af49-e45a3b3fe071
DOI: 10.1101/573030

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