Automated Fast-Flow Synthesis of Peptide Nucleic Acid Conjugates

Abstract excerpt

Peptide nucleic acids (PNAs) are charge-neutral oligonucleotides with emerging potential for treatment of genetic, acquired, and viral diseases, including COVID-19. Their challenging synthesis, however, limits their use for rapid therapeutic intervention and widespread application. Here, we report a highly efficient technology that utilizes a fully automated fast-flow instrument to manufacture cell-penetratin...

Topics

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• Advanced biosensing and bioanalysis techniques
• Biosensors and Analytical Detection
• CRISPR and Genetic Engineering
• RNA and protein synthesis mechanisms
• RNA Interference and Gene Delivery
• SARS-CoV-2 detection and testing
• Viral Infections and Immunology Research
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

f5f1deaa-52af-5268-8675-efd0f685798d

DOI

10.26434/chemrxiv.14099042.v1