Article

Definition of alleles and altered regulatory motifs across Cas9-edited cell populations

2019-09-19

Abstract excerpt

<h4>Background</h4> Genetic alteration of candidate response elements at their native chromosomal loci is the only valid determinant of their potential transcriptional regulatory activities. Targeted DNA cleavage by Cas9 coupled with cellular repair processes can produce arrays of alleles that can be defined by massively parallel sequencing by synthesis (SBS), presenting an opportunity to generate and survey edit...

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Literature Corpus work: 2cb7303a-4ecf-59cf-83ab-ccf8f54dbbe2
DOI: 10.1101/775361

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