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Article

Computational resources to define alleles and altered regulatory motifs at genomically edited candidate response elements.

Nucleic acids research - 20 Sept 2021

Ehmsen Kirk T, Knuesel Matthew T, Martinez Delsy, Asahina Masako, Aridomi Haruna, Yamamoto Keith R

Abstract excerpt

Unequivocal functional assessment of candidate genomic regulatory regions, such as transcriptional response elements, requires genetic alteration at their native chromosomal loci. Targeted DNA cleavage by Cas9 or other programmable nucleases enables analysis at virtually any genomic region, and diverse alleles generated by editing can be defined by deep sequencing for functional analysis. Interpretation of...

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Identifiers

PMID: 34417596
DOI: 10.1093/nar/gkab700
PMCID: PMC8450113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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