GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis

Abstract excerpt

Abstract Background Fibroblasts have important roles in the synthesis and remodeling of extracellular matrix (ECM) proteins during pulmonary fibrosis. However, the spatiotemporal distribution of heterogeneous fibroblasts during disease progression remains unknown. Results In the current study, silica was used to generate a mouse model of pathological changes in the lung, and single-cell sequencing, spatial...

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