Article

Molecular phenotypes that are causal to complex traits can have low heritability and are expected to have small influence

2014-09-22

Abstract excerpt

Work on genetic makeup of complex traits has led to some unexpected findings. Molecular trait heritability estimates have consistently been lower than those of common diseases, even though it is intuitively expected that the genotype signal weakens as it becomes more dissociated from DNA. Further, results from very large studies have not been sufficient to explain most of the heritable signal, and suggest hundreds...

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Literature Corpus work: 2cab30db-ed13-5582-ab5a-4b6eac2a304a
DOI: 10.1101/009506

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