Beyond genotype to phenotype: why the phenotype of an individual cannot always be predicted from their genome sequence and the environment that they experience.

Abstract excerpt

One promise of personalized medicine is that it will be possible to make useful predictions about the phenotypes of individuals from their complete genome sequences (e.g. concerning their susceptibility to disease). However, to what extent is knowledge about an individual's genotype, together with information about the environment that they have experienced, sufficient to predict phenotypic variation? In the...

Topics

• Environment
• Gene Expression Regulation
• Gene-Environment Interaction
• Genetic Variation
• Genome, Human
• Genotype
• Humans
• Inheritance Patterns
• Models, Genetic
• Phenotype