Back to search

Article

NUDT15 genotype and erythrocyte thioguanosine levels affect thiopurine metabolite levels into DNA of Japanese children with acute lymphoblastic leukemia

2024-07-22

Abstract excerpt

<title>Abstract</title> <p>Purpose This study aimed to measure thiopurine metabolites—such as deoxythioguanosine incorporated into DNA (DNA-TG)—and erythrocyte thioguanine nucleotides (TGNs) and methyl mercaptopurine (MMPN) levels in Japanese children with acute lymphoblastic leukemia (ALL). This study also evaluated the factors that elevate thiopurine metabolites incorporated into the DNA. Methods DNA-TG, eryt...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2c8391a7-49dd-5026-bf6b-39e98a4acb61
DOI
10.21203/rs.3.rs-4634919/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
NUDT15 genotype and erythrocyte thioguanosine levels affect thiopurine metabolite levels into DNA of Japanese children with acute lymphoblastic leukemiaDOI 10.21203/rs.3.rs-4634919/v1
The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia.Semantic proximity
DNA-thioguanine nucleotide as a treatment marker in acute lymphoblastic leukemia patients with NUDT15 variant genotypes.Semantic proximity
NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine TherapySemantic proximity
NUDT15 Polymorphism and Its Association With Mercaptopurine Hematotoxicity in Acute Lymphoblastic Leukemia in Indonesian Children.Semantic proximity
NUDT15 Variants Cause Hematopoietic Toxicity with Low 6-TGN Levels in Children with Acute Lymphoblastic Leukemia.Semantic proximity
Genotyping NUDT15 can predict the dose reduction of 6-MP for children with acute lymphoblastic leukemia especially at a preschool age.Semantic proximity
Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations.Semantic proximity
NUDT15 is a key genetic factor for prediction of hematotoxicity in pediatric patients who received a standard low dosage regimen of 6-mercaptopurine.Semantic proximity
NUDT15 genetic variants are related to thiopurine-induced neutropenia in Thai children with acute lymphoblastic leukemia.Semantic proximity
Importance of NUDT15 Polymorphisms in Thiopurine TreatmentsSemantic proximity
Emerging role of NUDT15 polymorphisms in 6-mercaptopurine metabolism and dose related toxicity in acute lymphoblastic leukaemia.Semantic proximity
Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestrySemantic proximity
Select a neighboring publication to make it the new centre.