Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations.

doi:10.1093/jnci/djae004

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Article

Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations.

Journal of the National Cancer Institute - 8 May 2024

Maillard Maud, Nishii Rina, Yang Wenjian, Hoshitsuki Keito, Chepyala Divyabharathi, Lee Shawn H R, Nguyen Jenny Q, Relling Mary V, Crews Kristine R, Leggas Mark, Singh Meenu, Suang Joshua L Y, Yeoh Allen E J, Jeha Sima, Inaba Hiroto, Pui Ching-Hon, Karol Seth E, Trehan Amita, Bhatia Prateek, Antillon Klussmann Federico G, Bhojwani Deepa, Haidar Cyrine E, Yang Jun J

Abstract excerpt

BACKGROUND: Thiopurines such as mercaptopurine (MP) are widely used to treat acute lymphoblastic leukemia (ALL). Thiopurine-S-methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) inactivate thiopurines, and no-function variants are associated with drug-induced myelosuppression. Dose adjustment of MP is strongly recommended in patients with intermediate or complete loss of activity of TPMT and NUDT15. However,...

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Identifiers

PMID: 38230823
DOI: 10.1093/jnci/djae004
PMCID: PMC11077315

Genes

NUDT15
TPMT
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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