Article
DNA-thioguanine nucleotide as a treatment marker in acute lymphoblastic leukemia patients with NUDT15 variant genotypes.
PloS one - 1 Jan 2021
Ju Hee Young, Lee Ji Won, Cho Hee Won, Hyun Ju Kyung, Ma Youngeun, Yi Eun Sang, Yoo Keon Hee, Sung Ki Woong, Choi Rihwa, Koo Hong Hoe, Lee Soo-Youn
Abstract excerpt
BACKGROUND: Large inter-individual variations in drug metabolism pose a challenge in determining 6-mercaptopurine (6MP) doses. As the last product of 6MP metabolism, DNA-thioguanine nucleotide (DNA-TGN) could reflect the efficacy of 6MP, especially in patients harboring variants in the 6MP metabolism pathway. The aim of this study was to investigate the clinical significance of DNA-TGN monitoring in Korean...
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